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Drug manufacturer Eli Lilly announced this week that an encouraging clinical test of their new pill promises an appropriate way, without a knife to treat diabetes and overweight.
Company shares increased 15% in the wake of the tests that showed the pill, called Orthglipron, helped patients with type 2 diabetes lose weight at levels comparable to major -injectable drugs such as Ozepic.
“This is a potentially high progress for patients who require a needle -free option for glucose weight and management,” Lilly said in a statement.
Experimental pills belong to the same class of medicines as Ozepic and Wegovy.
Known as GLP-1 receptor agonists, these medicines mimic a hormone called Peptid-1 similar to glucagon, which regulates appetite, secretion of insulin and blood sugar.
While initially developed to treat type 2 diabetes, GLP-1 drugs have increased in popularity for their ability to promote significant weight loss. The demand for these therapies has increased greatly in recent years.
But these medicines should be taken as a weekly injection, which limits entry, use and appeal, making the development of oral alternatives a major advantage for drug manufacturers.
If approved, the Orthglipron can reformulate the landscape by offering a more convenient, cost -friendly, comparable approach.
How long will customers have to wait for it to go on the market?
Representatives from Lilly said the company plans to require FDA approval to trade weight for weight this year and diabetes in 2026.
FDA review may last month, however analysts speculate that if things go to plan, Orthglipron may be made available in commercial in the US until the second half of next year.
In an effort to combat supply shortages, Lilly has been increasing his supply with pills.
The company recently discovered an inventory of nearly $ 550 million – specifically linked to the Orthodox and discovered the plans, if approved, to produce the entire US supply within five years.
How much will new weight loss pills cost?
The company is unlikely to set a drug price before receiving approval.
According to the New York Times, analysts suspect that the price of posters (initial price for insurance coverage negotiations) is likely to be below $ 1,000 a month, less lower than the company’s injectable treatments, Zepbound ($ 1,086) and Wegovy ($ 1,349).
What did the clinical trials find
Lillyâ’s clinical trial followed more than 500 people with type 2 diabetes who took the Orthition or a placebo for nearly 10 months.
Participants in the highest dose of the pill lost an average of 16 pounds, or nearly 8% of their body weight. This level of weight loss is consistent with the quantity spilled for the same period using ozepic.
ORFORGLPROP also lowered blood sugar levels by 1.3% on average.
What are the side effects?
In terms of side effects, Lilly reported that the most common complaints in the ORAFORGLPRON clinical test were diarrhea, indigestion, constipation, nausea and vomiting, the consequences in accordance with the use of LEGP-1 injectable medeles.
Lilly said Orthglipron trial participants showed no signs of liver damage.
Other developing pills
Lilly, which makes zepbound injectable medication to treat overweight and mounjaro and trullice to treat diabetes, is among a host of manufacturers competing to bring a needle -free medicine in the market.
Some other companies are in the midst of creating their GLP-1 pills. However, Orthglipron is further developing and theoretically, closer to the approval of the FDA.
This week the Pfizer drug manufacturer abandoned their development of a GLP-1 pill after a court participant experienced a liver damage caused by drugs .â €.
Lily is continuing to conduct other large -scale oroflypron studies, researching the effect of medicine on patients with diabetes, overweight and overweight related conditions such as sleep apnea and heart disease. Obestiy patients are expected later this year and with results from tests of patients with type 2 diabetes expected in early 2026.
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