Previous research has shown that vitamin D deficiency can increase the risk of multiple sclerosis (MS) – and a new study suggests that filling it in high doses can help reduce symptoms.
The study included 303 adults in France that had experienced clinically isolated syndrome (CIS) – which is a single, initial period of neurological symptoms that can lead to MS – within the last 90 days.
A group of participants received high doses (100,000 IU) of the Colalciferol (Vitamin D3) every two weeks for 24 months.
Among this group, 60.3% suffered a relapse of new or enlarged symptoms or lesions in MRI scans.
In comparison, 74.1% of those who received a placebo suffered the same effects – which is a “statistically significant change”, the researchers wrote from Chu NĂ®mes, University Montpellier and Multiple Sclerosis Centers in France.
The findings of the double blind study were published in the Jama magazine.
“The pre-ferialciferol oral 100,000 IU every two weeks significantly reduced the activity of the disease in CIA and the Early Removal MS,” the researchers writes.
“These results guarantee further investigations, including the potential role of high -dose pulse vitamin D as additional therapy.”
Bruce Bebo, executive vice president of the MS national society in Oregon, was not included in the research, but commented to the Fox News Digital for what he described as a “well -designed study”.
“These findings suggest that high -dose vitamin D can be a promising approach to reducing the activity of the disease in the early stages of MS,” he said.
However, studies previously published failed to associate vitamin D completion with reduced MS disease activity, although they used lower doses, according to Bebo.
“Overall, evidence suggests that the effects of vitamin D are likely to be modest, will require high doses and will be more effective when taken at the beginning of the disease by people who are deficient in vitamin D,” he said.
The American Academy of Neurology currently recommends a range of 300 to 4,000 units per day per adult, with 4,000 units as the highest dose recommended by most health authorities, Babo noted.
“It is important to note that Jama’s study used a significantly higher dose (100,000 units per day). While they did not report any adverse events, excessive vitamin D can be toxic,” he warned.
“High doses can cause excess calcium in the blood that leads to nausea, vomiting, weakness, frequent urination and, in some cases, kidney damage.
Anyone with MS who is interested in completing vitamin D should discuss it with a neurologist or primary health care provider to determine the best approach, he recommended.
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